P-selectin mediates neutrophil rolling and recruitment in acute pancreatitis. Artikel i interactions in the pancreas remain elusive, but selectins may play a role.

2019-07-12

Article. Oct 2013; Platelets. Novartis P-selectin-hämmare Adakveo har rekommenderats och godkänts av EU CHMP och har listats i 8 länder! Mastceller; Vasdilation; P-selectin. PGD2, PGE2.

[PubMed:7585950] Wilkins PP, Moore KL, McEver RP, Cummings RD: Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin. P selectin,leukocyte adhesion molecule,granule membrane protein (platelet,endothelium),induced by thrombin,histamine,peroxides from platelet alpha granule,high expressed in atherosclerotic plaques SELP Mechanisms for increasing synthesis of P-selectin are suggested by its presence on the apical surface of endothelial cells in human tissues with chronic or allergic inflammation.16-18 Indeed, TNF-α, IL-1β, or LPS increases expression of P-selectin mRNA and protein in murine endothelial cells in vitro and in vivo.10,19,20 Transient activation of the murine P-selectin gene requires the cooperative binding of NF-κB, ATF-2, and other transcription factors.21 However, the binding sites for NF Search results for p selectin at Sigma-Aldrich. Summary: This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. P-selectin, also called GMP-140, CD62, or selectin P, is a 140-kD adhesion molecule, expressed at the surface of activated cells, that mediates the interaction of activated endothelial cells or platelets with leukocytes. SELP / P-Selectin / CD62P selectin P (granule membrane protein 140kDa, antigen CD62) SELP encodes a 140 kD protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. The P-selectin ligand, PSGL-1, plays an essential role in the initial recruitment of leukocytes to the site of injury during inflammation. During inflammation, when endothelial cells are activated by molecules such as histamine or thrombin, within minutes, P-selectin moves from an internal cell location to the endothelial cell surface.

Bgee i: ENSG00000174175, Expressed in adrenal gland and 157 other tissues ExpressionAtlas i: P16109, baseline and differential: Genevisible i: P16109, HS: Organism-specific 2018-11-16 P-Selectin Subject Areas on Research 2016-06-29 P-selectin, traditionally regarded as a simple adhesion receptor is also capable of expediting platelet aggregation and secretion [23,24].

Recombinant Human P-Selectin Protein (Met1-Ala771) 13025-H02H with a fusion hFc Tag, is expressed in HEK293 Cells. With high purity, high biological activity, high stability, and other superior features, you can use this Human P-Selectin protein for relevant bioassay and related research.

J Biol Chem. 1995 Sep 29;270(39):22677-80.

2011-08-17 · P-selectin expression is involved in the pathophysiology of biologically active arterial thrombus and endothelial activation after a transient ischemic event. Fucoidan is a polysaccharidic ligand of P-selectin, with a nanomolar affinity. In the present study, we propose a new approach of P-selectin molecular imaging based on radiolabeled fucoidan. Methods: Two kinds of experimental models were

Oct 2013; Platelets. Novartis P-selectin-hämmare Adakveo har rekommenderats och godkänts av EU CHMP och har listats i 8 länder! Mastceller; Vasdilation; P-selectin.

Although present on the external cell surfa … P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling.
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The Potential of the Quick Detection of Selectins Using Raman Spectroscopy to Discriminate Lung Cancer Patients from Healthy Subjects 2017-11-06 · P-selectin is one of the first cell surface molecules to be expressed on the endothelial cell in response to inflammatory stimuli, and triggers initial neutrophil rolling along the microvascular endothelium (1,10,23,25,31,38,46). Its expression on the endothelial cell lumenal P-Selectin (also called GMP-140) expressed on activated platelets and endothelial cells. Selectins interact with specific carbohydrates expressed by activated endothelial cells, monocytes, and neutrophils.

P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. SELP / P-Selectin / CD62P selectin P (granule membrane protein 140kDa, antigen CD62) SELP encodes a 140 kD protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells.
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The present research collaboration aims to study platelet cross-talk with lymphocytes and BM-PCs during atherogenesis, and to investigate P-selectin- and

Selectins interact with specific carbohydrates expressed by activated endothelial cells, monocytes, and neutrophils. The P-selectin expression in serum and lung tissues of KPN pneumoniae-inoculated ICH mice in the KPN + ICH group was higher than those in the KPN and ICH groups (; Figure 6(a)). Then, the effect of P-selectin on severe acute lung injury induced by Klebsiella pneumoniae in immunocompromised mice was evaluated in subsequent experiments. selectin: ( sĕ-lek'tin ), A cell surface molecule involved in immune adhesion and cell trafficking.

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P-selectin is a leukocyte adhesion receptor present in endothelial cells and platelets. We examined the role of P-selectin in the autologous phase of an

1995 Oct 20;83(2):333-43.