A population of myeloid-derived suppressor cells (MDSCs), abundantly producing the pro-inflammatory S100A9 protein, promotes myeloma progression. Tasquinimod (TASQ) is an investigational drug that targets MDSCs via the S100A9 protein.

2017-04-14

Detailed Description Tasquinimod has previously been studied as an anti-cancer agent in patients with other cancers, including a phase 3 randomized trial in patients with metastatic prostate cancer that showed an improvement in radiographic progression-free survival. This study is the first study of tasquinimod, an inhibitor of S100A9, in patients with multiple myeloma. Tasquinimod is an oral immunomodulatory and anti-angiogenic investigational treatment, that affects the tumor's ability to grow and metastasize. Tasquinimod is developed as a new immunomodulatory treatment for multiple myeloma. This trial will establish a maximum tolerated dose and optimal schedule for administration of tasquinimod in patients with multiple myeloma and then investigate the maximum tolerated dose of tasquinimod in combination with a standard myeloma regimen of ixazomib, lenalidomide, and dexamethasone (IRd). The introduction of proteasome inhibitors in to the multiple myeloma healing armamentarium has resulted in a dramatic improvement in scientific outcomes (1C5). Nevertheless, despite these advancements, multiple myeloma cells undoubtedly develop level of resistance to proteasome inhibition Tasquinimod resulting in disease development.

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Tasquinimod (TASQ) is an investigational drug that targets MDSCs via the S100A9 protein. Tasquinimod, an oral immunomodulator, is in clinical development for treatment of multiple myeloma, NCT04405167. Laquinimod, an immunomodulator, is evaluated as a potential treatment of the eye Multiple Myeloma In a recent press release, Swedish biotechnology company Active Biotech announced that the first patient in their Phase 1b/2a clinical trial received a dose of tasquinimod. The trial will examine the efficacy and tolerability of tasquinimod on its own and in combination with other therapies for patients with multiple myeloma. The small molecule immunomodulatory drug tasquinimod has been designated an orphan drug by the U.S. Food and Drug Administration (FDA) for the treatment of multiple myeloma, according to Active Biotech. Tasquinimod (ABR-215050, Active Biotech, Lund, Sweden) is an investigational drug that binds the S100A9 protein and inhibits the interactions with its receptors.

Clinical effects and an overall good tolerability have been demonstrated in 1500 patients, representing more than 650 patient-years of exposure to tasquinimod. Today, tasquinimod is in development for treatment of multiple myeloma, a rare form of blood cancer with a high Tasquinimod (TASQ) is an investigational drug that targets MDSCs via the S100A9 protein. In pre-clinical models of MM, TASQ has significant anti-tumor effects as a single agent and in combination with bortezomib, a proteasome inhibitor (PI) and lenalidomide, an immunomodulator (IMiD) (Lin C, et al.

Active Biotech announces first patient dosed in phase 1b/2a study of tasquinimod use in treatment of multiple myeloma. Active Biotech. Lund Sweden, August 3, 2020 - …

Active Biotech is seeking a partner for the continued development of tasquinimod in multiple myeloma. Active Biotech AB (publ) Idag är tasquinimod under utveckling för behandling av multipelt myelom, en ovanlig fo rm av blodcancer med ett stort medicinskt behov.

This study is the first study of tasquinimod, an inhibitor of S100A9, in patients with multiple myeloma. Tasquinimod has previously been studied as an anti-cancer agent in patients with other cancers, including a phase 3 randomized trial in patients with metastatic prostate cancer that showed an improvement in radiographic progression-free survival.

Tasquinimod is developed as a new immunomodulatory treatment for multiple myeloma. This trial will establish a maximum tolerated dose and optimal schedule for administration of tasquinimod in patients with multiple myeloma and then investigate the maximum tolerated dose of tasquinimod in combination with a standard myeloma regimen of ixazomib, lenalidomide, and dexamethasone (IRd). The introduction of proteasome inhibitors in to the multiple myeloma healing armamentarium has resulted in a dramatic improvement in scientific outcomes (1C5). Nevertheless, despite these advancements, multiple myeloma cells undoubtedly develop level of resistance to proteasome inhibition Tasquinimod resulting in disease development.

Tasquinimod is developed as a new immunomodulatory This study is the first study of tasquinimod, an inhibitor of S100A9, in patients with multiple myeloma. Tasquinimod has previously been studied as an anti-cancer agent in patients with other cancers, including a phase 3 randomized trial in patients with metastatic prostate cancer that showed an improvement in radiographic progression-free survival. 2020-08-12 · Researchers believe that tasquinimod fits an unmet need in the multiple myeloma community who need a wider array of safe and effective treatment options. Multiple Myeloma. While doctors aren’t sure what causes multiple myeloma (a blood cancer that develops in plasma cells), some hypothesize that it relates to a deficient or missing chromosome 13. 2016-03-23 · Lund, March 23, 2016 - Active Biotech (Nasdaq Stockholm: ACTI) today announces that a patent application for the treatment of multiple myeloma with the company's compound tasquinimod, together 2017-04-14 · Lund 12 April 2017 – Active Biotech AB (Nasdaq Stockholm:ACTI) announces today that Active Biotech has been granted Orphan Drug Designation by the U.S. Food and Drug Administration (FDA) for its investigational novel agent tasquinimod, for the treatment of multiple myeloma. myeloma.
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Lund January 9, 2017 - Active Biotech AB announces today that the European Patent Office has decided to grant Active Biotech's patent application covering tasquinimod for use in | March 30, 2021 Active Biotech meddelar att första patienten har doserats i fas 1b/2a-studien med tasquinimod för behandling av multipelt myelom Active Biotech Lund Sverige, 3 augusti, 2020 - Active Biotech (NASDAQ STOCKHOLM: ACTI) tasquinimod inom multipelt myelom. Nya prekliniska data från experimentella modeller för multipel myelom, som visar att tasquinimod har effekt som monoterapi och i kombination med standard­ behandling, presenterades i juni på den virtuella konferensen European Hematology Association Meeting. För både tasquinimod som monoterapi och kombinationen av tasquinimod och IRd kommer utvidgade kohort-studier att utföras för att undersöka anti-myelom aktivitet för respektive behandling. Studiens primära mål är att fastställa optimal dos och behandlingsschema för tasquinimod som monoterapi och i kombination med IRd. Tasquinimod acts on immunosuppressive cells that play a key role in tumor progression in multiple myeloma due to their capability to promote immune-escape, angiogenesis, and metastasis. Robust results have been achieved with tasquinimod in animal models for multiple myeloma.

Active Biotech, of Lund, Sweden, Tasquinimod, Immunomodulatory and anti- angiogenic, Relapsed or refractory multiple myeloma, First of up to 54 patients  26. feb 2021 Tasquinimod, is in clinical phase Ib/IIa for treatment of multiple myeloma. Laquinimod is advancing to phase II for treatment of non-infectious  However, in certain cancers, such as melanoma, multiple myeloma, and prostate Tasquinimod modulates suppressive myeloid cells and enhances cancer  26 feb 2021 Tasquinimod, is in clinical phase Ib/IIa for treatment of multiple myeloma. Laquinimod is advancing to phase II for treatment of non-infectious  Tasquinimod, an immunomodulator, will enter a Phase Ib/IIa trial on multiple myeloma in partnership with the University of Pennsylvania Medical School.
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3 aug 2020 För både tasquinimod som monoterapi och kombinationen av med givna responskriterier från International Myeloma Working Group. Studien 

Tasquinimod is developed as a new immunomodulatory treatment for multiple myeloma. This trial will establish a maximum tolerated dose and optimal schedule for administration of tasquinimod in patients with multiple myeloma and then investigate the maximum tolerated dose of tasquinimod in combination with a standard myeloma regimen of ixazomib, lenalidomide, and dexamethasone (IRd). The introduction of proteasome inhibitors in to the multiple myeloma healing armamentarium has resulted in a dramatic improvement in scientific outcomes (1C5).